Treatment Terminology The procedure may be performed using a wire loop heated by electrical current (LEEP procedure), a scalpel (cold knife biopsy), or a laser beam. Use a uterine sound to mark a depth of 2 cm within the endo-cervical canal, typically the most cephalad margin of the cone. Recurrence of abnormal cervical cells : The risk tends to be lowest for cold knife conization (less than 2%) when compared to LEEP and cryosurgery (use of cold to destroy abnormal tissue). LEEP is often preferred over a cold knife cone since it affords less blood loss, is performed more quickly, and can be done in an office setting 1). Methods. Success and complication rates were the same for the two methods. with the use of cold knife cone biopsy; however, LEEP is fast-er, cheaper and involves fewer complications [4]. It usually takes about 4 to 6 weeks for your cervix to heal after this procedure. Abnormal cytology after conization was found in a total of 53 cases (12.5%), but a histologic confirmation of residual or recurrent CIN was made in only 27 women (6.4%). LEEP conization is a safe and cost effective procedure with a lower complication rate providing a significantly smaller specimen compared to cold knife conization. Wide conization with adequate evaluation of the surgical margins is considered sufficient to treat high-grade lesions. Objective.   Preterm delivery: This is uncommon but can happen as a result of a cone biopsy. Cold Knife Cone Biopsy Success Rate. Risk of recurrence lower with cold knife cone. Treatment success of LEEP is reported as 98% 2), 96% 3), 96% 4), 95% 5), 91% 6) and 94% 7) in non-randomized studies. Loop excision cones were significantly shallower than those obtained by a cold knife. The cervical canal above the cone biopsy may also be scraped to remove cells for evaluation. To compare the histomorphologic and colposcopic results of cold knife conization and loop excision. CONCLUSIONS: Loop excision provides a sample that is adequate for histologic evaluation in most cases, results in the same success rate as cold knife conization, and allows optimal colposcopic surveillance in significantly more cases than cold knife excision. The cold knife cone biopsy success rate varies from 60% to 80%. In some cases, patients die within one year after the surgery. Allows assessmentof surgical margins Success rates high with both LEEP and cold knife cone. If the patient survives, it may take up to two years before they are able to walk again. During a cone biopsy, your doctor will remove a small, cone-shaped part of your cervix. However, the finding of a residual lesion following conization This corresponds to a success rate of 92% after cold-knife and 95% after laser conization. To perform a cold-knife cone, use a #11 surgical blade to begin a circular incision starting at 12 o’clock on the face of the cervix, angling the tip of the blade toward the endocervical canal . The rate of complete resection was 91% in the cold knife and 82% in the loop excision group, but histologic confirmation of residual CIN was obtained in only 2 (1.7%) women after cold knife conization and in 5 (4.2%) after loop excision. A small cone-shaped sample of tissue is removed from the cervix. Sixty-six women were randomly allocated to have the cone specimen removed by cold knife excision (n = 38) or loop excision (n = 28).Subjects eligible for inclusion were those who presented histologically verified grade 3 cervical intraepithelial neoplasia (CIN) or … Perinatal risks in subsequent pregnancy higher with cold knife cone. This is call an endocervical curettage (ECC). 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